Table 1 |
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Functional categorisation of differentially expressed genes in wild type, mTERC -/- and PARP-1-/- MEFs following arsenite treatment. |
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|
Gene Name |
GeneBank ID |
mTERC-/- |
PARP-1-/- |
|
|
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|
Cell death |
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|
Aifm2 |
6.50 |
4.50 |
|
|
Bcl2l11 |
3.47 |
2.22 |
|
|
Siva |
3.37 |
1.24 |
|
|
Sphk1 |
3.22 |
3.35 |
|
|
Pik3r1 |
1.24 |
-2.45 |
|
|
Birc1f |
-1.58 |
-2.15 |
|
|
IAP1 |
-2.55 |
-1.72 |
|
|
FLG |
-3.13 |
-1.65 |
|
|
Casp9 |
-3.78 |
1.68 |
|
|
Faim-L |
-4.24 |
-1.38 |
|
|
Fam |
-8.56 |
-1.33 |
|
|
Birc6 |
-9.20 |
-2.41 |
|
|
Dad1 |
-9.29 |
-1.67 |
|
|
Cycs |
-9.47 |
-2.83 |
|
|
Stk17b |
-9.94 |
1.01 |
|
|
Il-6 |
-12.48 |
-8.72 |
|
|
Bip |
-20.04 |
-3.15 |
|
|
DNA damage response |
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|
Brca2 |
-1.64 |
-2.09 |
|
|
Xrn2 |
-1.82 |
-1.01 |
|
|
H2afx |
-2.04 |
-2.03 |
|
|
Ddb2 |
-2.07 |
1.16 |
|
|
Rad51ap1 |
-2.31 |
-2.59 |
|
|
Ercc5 |
-2.32 |
-1.33 |
|
|
Gadd45a |
-2.57 |
-1.67 |
|
|
Mlh1 |
-2.82 |
-1.46 |
|
|
Msh6 |
-2.94 |
-1.56 |
|
|
Chek2 |
-3.09 |
-1.72 |
|
|
1110013J05Rik |
-3.17 |
-2.17 |
|
|
Lig4 |
-4.01 |
-1.95 |
|
|
Sod1 |
-6.15 |
-1.81 |
|
|
Mapk14 |
-7.63 |
-2.63 |
|
|
Telomere homeostasis |
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|
Smg6 |
3.18 |
6.26 |
|
|
Adprt1 |
2.49 |
-4.06 |
|
|
Terf2 |
2.01 |
-2.23 |
|
|
Hspa1b |
1.28 |
1.43 |
|
|
Blm |
1.02 |
-2.77 |
|
|
DNA-PK |
-1.98 |
-3.18 |
|
|
|
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|
Expression profile of selected genes, which were differentially expressed to a fold change of 2.0 or more in one of the treatments are given. Data indicate the fold increase (positive values) or decrease (negative values) in treated samples compared to corresponding normal controls. |
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|
Gurung et al. Genome Integrity 2010 1:5 doi:10.1186/2041-9414-1-5 |
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