Table 1 |
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|
Increased chromosomal instability in UHRF1-depleted cellsa. |
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|
Cell line |
Chromosome Breaks |
Chromatid Breaks |
Fusions |
Fragments |
Total No. of aberrations |
|
|
|||||
|
Control shRNA-1 |
0 |
0 |
1 (0.02/cell) |
8 (0.16/cell) |
9 (0.18/cell) |
|
Control shRNA-2 |
0 |
0 |
2 (0.04/cell) |
12 (0.24/cell) |
14 (0.28/cell) |
|
Control shRNA-3 |
2 (0.04/cell) |
0 |
3 (0.06/cell) |
10 (0.2/cell) |
15 (0.3/cell) |
|
UHRF1 shRNA-1 |
1 (0.02/cell) |
0 |
5 (0.1/cell) |
47 (0.94/cell) |
53 (1.06/cell) |
|
UHRF1 shRNA-2 |
1 (0.02/cell) |
0 |
5 (0.1/cell) |
51 (1.02/cell) |
57 (1.14/cell) |
|
UHRF1 shRNA-3 |
9 (0.18/cell) |
1 (0.02/cell) |
1 (0.02/cell) |
54 (1.08/cell) |
65 (1.3/cell) |
|
|
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|
aResults shown are number of chromosomal abnormalities detected in fifty metaphase spreads from three control shRNA and three UHRF1 shRNA (UHRF1-depleted) cell lines. The frequency of a given abnormality/metaphase is shown below in parentheses. |
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|
Mistry et al. Genome Integrity 2010 1:7 doi:10.1186/2041-9414-1-7 |
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