Genome Integrity

Editors-in-Chief

M Prakash Hande, National University of Singapore
Predrag Slijepcevic, Brunel University, London
Razqallah Hakem, University of Toronto
John Petrini, Memorial Sloan-Kettering Cancer Center, New York

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Articles

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Research

Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer

Facista A, Nguyen H, Lewis C, Prasad AR, Ramsey L, Zaitlin B, Nfonsam V, Krouse RS et al. Genome Integrity 2012, 3:3 (11 April 2012)
Research

Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

AshaRani PV, Sethu S, Lim HK, Balaji G, Valiyaveettil S and Hande MP Genome Integrity 2012, 3:2 (10 February 2012)
Research

Development and validation of 'AutoRIF': software for the automated analysis of radiation-induced foci

McVean A, Kent S, Bakanov A, Hobbs T and Anderson R Genome Integrity 2012, 3:1 (26 January 2012)
Research

Direct Detection and Sequencing of Damaged DNA Bases

Clark TA, Spittle KE, Turner SW and Korlach J Genome Integrity 2011, 2:10 (20 December 2011)
Research

Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells

Sapir E, Gozaly-Chianea Y, Al-Wahiby S, Ravindran S, Yasaei H and Slijepcevic P Genome Integrity 2011, 2:9 (9 December 2011)
Research

Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability

Doerfler L, Harris L, Viebranz E and Schmidt KH Genome Integrity 2011, 2:8 (31 October 2011)
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Table 3 (Minor Correction)

Comment on: Doerfler et al. Genome Integrity 2012, 2:8

Aims & scope

Genome Integrity is an open access journal that publishes research on all aspects of genome integrity, the cellular processes underlying maintenance of genome stability, and the effects of instability.

The processes that regulate genome integrity maintenance include sensing, signalling and repair of DNA damage, processing of DNA damage in the context of chromatin and chromosomes, cell cycle checkpoint control and control of apoptosis. Effective maintenance of genome integrity is essential for normal cell division, tissue homeostasis, healthy organismal ageing and prevention of diseases such as cancer. A number of model systems including single cell organisms and various higher plant and animal species, as well as studies of human cells/tissues or patients are required to understand how genome integrity maintenance affects ageing and development of cancer.