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Open Access Commentary

Fanconi-like crosslink repair in yeast

Danielle L Daee and Kyungjae Myung*

Author Affiliations

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD, 20892, USA

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Genome Integrity 2012, 3:7  doi:10.1186/2041-9414-3-7

Published: 12 October 2012

Abstract

Interstrand crosslinks covalently link complementary DNA strands, block replication and transcription, and can trigger cell death. In eukaryotic systems several pathways, including the Fanconi Anemia pathway, are involved in repairing interstrand crosslinks, but their precise mechanisms remain enigmatic. The lack of functional homologs in simpler model organisms has significantly hampered progress in this field. Two recent studies have finally identified a Fanconi-like interstrand crosslink repair pathway in yeast. Future studies in this simplistic model organism promise to greatly improve our basic understanding of complex interstrand crosslink repair pathways like the Fanconi pathway.

Keywords:
Fanconi anemia; Interstrand crosslink repair; Mph1; Chl1; Slx4; Msh2; Msh6; Mhf1; Mhf2